Why the study?
Does invasive hemodynamics at exercise allow for the diagnosis of stiff left atrial syndrome when noninvasive investigations are inconclusive?
Does invasive hemodynamics at exercise allow for the diagnosis of stiff left atrial syndrome when noninvasive investigations are inconclusive?
Invasive hemodynamics during exercise can be crucial for diagnosing stiff left atrial syndrome in patients with exertional breathlessness when noninvasive testing is inconclusive.
Exercise hemodynamics may diagnose stiff LA syndrome missed noninvasively; hypothesis-generating for radiotherapy-related HFpEF.
Stiff left atrial (LA) syndrome is a distinct phenotype of heart failure with preserved ejection fraction, characterized by predominant high LA pressure. We describe the case of a middle-aged woman who developed exertional breathlessness during low-dose radiotherapy for right breast cancer and who was eventually found to be affected by stiff LA syndrome. Invasive hemodynamics allowed the recognition of pathognomonic tall V waves in the wedge position during exercise, in spite of inconclusive noninvasive investigations.
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Baratto et al. (2019) studied this question.
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