Why the study?
Does intravenous 1-noradrenaline infusion cause an enhanced pressor response in subjects tetraplegic from cervical spinal cord transections compared to controls?
Population
Subjects tetraplegic from cervical spinal cord transections
Comparison
Intravenous infusions of 1-noradrenaline vs Control subjects
Design
Case-control
Authors
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May warrant caution with noradrenaline dosing in cervical tetraplegia; leaves open baroreflex mechanisms in autonomic dysfunction.
Does intravenous 1-noradrenaline infusion cause an enhanced pressor response in subjects tetraplegic from cervical spinal cord transections compared to controls?
Tetraplegic subjects exhibit an enhanced pressor response to noradrenaline infusions, likely due to the loss of baroreceptor reflexes with sympathetic efferent pathways rather than post-ganglionic sympathetic denervation.
Mathias et al. (1976) studied this question.
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