18F-Fluoroestradiol PET/CT Correctly Diagnosed 18F-FDG–Avid Inflammatory Lymph Nodes in a Patient With Estrogen Receptor–Positive Breast Cancer

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A 77-year-old woman with left breast cancer received F-FDG PET/CT for initial staging, and F-FDG-avid lymph nodes were observed in the bilateral axillae. As estrogen receptor (ER) status of primary lesion was positive, the patient also received F-fluoroestradiol (F-FES) PET/CT. Unlike primary lesion, no remarkable F-FES uptakes in the lymph nodes were observed. F-FDG uptakes in the nodes were finally interpreted as inflammation. F-FES PET that can noninvasively evaluate the ER status may have a potential to reveal the pathology of the false-positive lesion observed in F-FDG PET for patients with ER-positive breast cancer.