What question did this study set out to answer?

To investigate the uptake of 18F-fluoroestradiol in benign nodular sclerosing adenosis of the breast.

January 16, 2026Clinical Nuclear Medicine0 citations

18FFluoroestradiol Uptake in Benign Nodular Sclerosing Adenosis of the Breast

ILIsmaheel O. LawalEmory University RSRebecca L. SeidelEmory University XLXiaoxian LiEmory University

Key Points

To investigate the uptake of 18F-fluoroestradiol in benign nodular sclerosing adenosis of the breast.
Patient aged 70 with ER+ invasive ductal carcinoma underwent 18F-FES PET/CT
MRI-guided biopsy of enhancing 18F-FES-avid region
Immunohistochemistry for estrogen receptor status
18F-FES uptake was observed in both invasive carcinoma and benign tissue
Biopsy revealed nodular sclerosing adenosis with 30% ER positivity
Highlights potential for false-positive 18F-FES uptake due to ER overexpression

Abstract

A 70-year-old woman with estrogen receptor-positive (ER+) invasive ductal carcinoma (IDC) of the right breast underwent 18 F-fluoroestradiol ( 18 F-FES) PET/CT demonstrating uptake in the IDC (SUVmax 2.5) and also extensive 18 F-FES uptake in bilateral breasts corresponding to marked bilateral background enhancement on MRI. MRI-guided biopsy of a representative enhancing 18 F-FES-avid region in the left breast (SUVmax 3.5) revealed nodular sclerosing adenosis without cellular atypia or malignancy, but with 30% ER positivity on immunohistochemistry. False-positive uptake of 18 F-FES is reported in irradiated lung and interstitial lung disease. This case highlights another mechanism of false-positive 18 F-FES uptake due to ER overexpression in benign breast tissue.

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