Key result
Carotid intima-media thickness (cIMT) and pulse wave velocity (PWV) are the most promising non-invasive methods for pediatric post-transplant CV risk assessment due to available normative values.
Why the study?
Cardiovascular risk remains elevated in children after kidney transplantation, yet large longitudinal studies and hard cardiovascular endpoints are usually lacking in the pediatric population. Validated adult non-invasive methods to assess cardiovascular damage require adaptation, standardization, and validation for pediatric use.
Carotid intima-media thickness (cIMT) and pulse wave velocity (PWV) are the most promising non-invasive methods for assessing cardiovascular risk in children following kidney transplantation due to the availability of pediatric normative values.
Dégi A, Kerti A, Kis É, Cseprekál O, Tory K, Szabó AJ, Reusz GS. Cardiovascular risk assessment in children following kidney transplantation. Abstract: CV diseases are the leading cause of death among patients with ESRD. RTX decreases the CV risk; however, it still remains definitely higher than that of the general population. Large multicenter and longitudinal studies are difficult to perform and hard end‐points of CV events are usually missing among pediatric population. Thus, appropriate estimation of CV risk is of crucial importance to define the potential hazards and to evaluate the effect of treatments aimed to reduce the risk. A number of validated non‐invasive methods are available to assess the extent of CV damage in adults, such as calcification scores, cIMT, aPWV, 24‐h ABPM, AASI, and HRV; however, they need adaptation, standardization, and validation in pediatric studies. cIMT and PWV are the most promising methods, as pediatric normative values are already present. The up‐to‐date treatment of ESRD aims not only to save life, but to offer the patient a life expectancy approaching that of the healthy population and to ensure a reasonable quality of life.
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Dégi et al. (2012) conducted a review in Cardiovascular risk in children following kidney transplantation. Non-invasive cardiovascular risk assessment methods (cIMT, PWV, calcification scores, 24-h ABPM, AASI, HRV) was evaluated. Carotid intima-media thickness (cIMT) and pulse wave velocity (PWV) are the most promising non-invasive methods for pediatric post-transplant CV risk assessment due to available normative values.
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