November 1, 1998Arteriosclerosis Thrombosis and Vascular Biology

Frequency of ApoB and ApoE Gene Mutations as Causes of Hypobetalipoproteinemia in the Framingham Offspring Population

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Structured PICO

Population

3873 subjects participating in the Framingham Offspring Study, including 75 subjects with persistent hypobetalipoproteinemia (HBLP, defined as LDL-C <70 mg/dL on at least 2 observations).

Comparator

Subjects with LDL-C ≥70 mg/dL

Outcome

Prevalence of truncated apoB and E2/E3 genotype as causes of HBLP

In the Framingham Offspring Population, hypobetalipoproteinemia is more commonly associated with the E2/E3 genotype rather than truncated apoB mutations.

Limitations

A large prospective study is needed to evaluate the incidence of cancer and atherosclerosis in subjects with HBLP

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports considering apoE genotyping in hypobetalipoproteinemia evaluation; hypothesis-generating and should not yet change practice.

Cite This Study

Welty et al. (1998) studied this question.

synapsesocial.com/papers/6a7c062fcbabed012ec631cc https://doi.org/10.1161/01.atv.18.11.1745

View Full Paper

Ask AI

Bookmark

Frequency of ApoB and ApoE Gene Mutations as Causes of Hypobetalipoproteinemia in the Framingham Offspring Population

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Frequency of ApoB and ApoE Gene Mutations as Causes of Hypobetalipoproteinemia in the Framingham Offspring Population

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider