Population
Persons with hypobetalipoproteinemia (LDL cholesterol levels equal to or less than the fifth percentile)
Design
Review
Authors
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Warrants caution in targeting apoB for extreme LDL reduction; leaves open whether hypobetalipoproteinemia mutations confer net survival benefit.
This review summarizes the genetic and molecular mechanisms underlying hypobetalipoproteinemias, highlighting their association with reduced cardiovascular risk and specific genetic mutations.
Gustav Schonfeld (1995) studied this question.
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