Why the study?
Does selective p38alpha MAPK inhibition with SD-282 improve cardiac function and reduce myocardial apoptosis in a rat model of myocardial injury?
Does selective p38alpha MAPK inhibition with SD-282 improve cardiac function and reduce myocardial apoptosis in a rat model of myocardial injury?
In a rat model of myocardial injury, selective p38alpha MAPK inhibition with SD-282 improved cardiac function and reduced myocardial inflammation and apoptosis.
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Offers preclinical rationale for p38α inhibition; leaves open translation to human myocardial injury.
Li et al. (2006) studied this question.
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