Cross-Sectional Associations Bet ween Abdominal and Thoracic Adipose Tissue Compartments and Adiponectin and Resistin in the Framingham Heart Study
Why the study?
Are regional fat depots associated with circulating adiponectin and resistin concentrations in individuals free of cardiovascular disease?
Population
916 participants from the Framingham Heart Study offspring cohort, 55% women, mean age 59 years, free of…
Design
Cross-sectional
Authors
Discussion
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Overview
Regional fat-adipokine correlations in CVD-free adults are hypothesis-generating; prospective studies needed to clarify mediation of cardiometabolic risk.
Structured PICO
Are regional fat depots associated with circulating adiponectin and resistin concentrations in individuals free of cardiovascular disease?
P
Population
916 participants from the Framingham Heart Study offspring cohort, 55% women, mean age 59 years, free of cardiovascular disease.
I
Intervention
Regional fat depots (visceral adipose tissue [VAT], subcutaneous adipose tissue [SAT], pericardial fat, and intrathoracic fat volumes) measured by computed tomography
O
Outcome
Circulating adiponectin and resistin concentrations, and their mediating effect on associations between abdominal fat depots and cardiometabolic risk factorssurrogate
Regional fat depots are correlated with adiponectin and resistin, but these adipokines do not fully explain the relationship between fat depots and cardiometabolic risk factors.
Cite This Study
Jain et al. (2009) studied this question.