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January 1, 1985The Journal of PhysiologyOpen Access

Currents carried by monovalent cations through calcium channels in mouse neoplastic B lymphocytes.

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Population

Hybridoma cell line constructed by fusion of S194 myeloma cells and splenic B lymphocytes from the mouse

Comparison

Alteration of external and internal ion… vs Normal/baseline ion concentrations

Design

Preclinical

Authors

YFYumiko FukushimaTaisho Pharmaceutical (Japan)SHSusumu HagiwaraNihon University

Discussion

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Implication

Supports voltage-dependent divalent block of Ca channels; extends selectivity models but leaves open cardiac relevance.

Structured PICO

P
Population
Hybridoma cell line (MAb-7B) constructed by fusion of S194 myeloma cells and splenic B lymphocytes from the mouse (n=62 for reversal potential measurement)
I
Intervention
Alteration of external and internal ion concentrations (Ca2+, Na+, Cs+, tetraethylammonium, Mn2+, Sr2+, Ba2+, Mg2+)
C
Comparator
Normal/baseline ion concentrations
O
Outcome
Membrane currents through the Ca2+ channel (reversal potential, inward/outward currents, decay time constant, voltage-dependent inactivation)surrogate

Monovalent cations can carry inward current through Ca2+ channels in mouse neoplastic B lymphocytes when external Ca2+ or Mg2+ is reduced, and this is blocked by divalent cations in a voltage-dependent manner.

Cite This Study

Fukushima et al. (1985) studied this question.

synapsesocial.com/papers/6a7c102fa540d02696c2bf16https://doi.org/10.1113/jphysiol.1985.sp015550
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Also Consider

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  1. 1Effects of calcium and calcium‐chelating agents on the inward and outward current in the membrane of mollusc neurones1977 · 274 citations
  2. 2A non‐selective cation conductance in frog muscle membrane blocked by micromolar external calcium ions.1984 · 306 citations
  3. 3Studies of calcium channels in rat clonal pituitary cells with patch electrode voltage clamp1982 · 268 citations
  4. 4The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve1971 · 750 citations
  5. 5Calcium Channel1981 · 1,191 citations