Why the study?
Do specific maternal and fetal risk factors increase the prevalence of congenital heart defects in singleton pregnancies?
Population
35,831 singleton pregnancies undergoing planned fetal echocardiography screening during the second trimester
Comparison
Presence of risk factors for CHDs vs Absence of risk factors
Design
Cohort
Authors
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Risk factors may support selective fetal echocardiography; hypothesis-generating for IVF and pregnancy factors pending prospective validation.
Do specific maternal and fetal risk factors increase the prevalence of congenital heart defects in singleton pregnancies?
Pregnancy- and fetus-related risk factors, as well as in vitro fertilization, are strong independent predictors of congenital heart defects, supporting targeted fetal echocardiography screening.
Pavlíček et al. (2018) studied this question.
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