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April 1, 1995Acta Anaesthesiologica Scandinavica

Oral premedication one hour before minor gynaecological surgery — does it have any effect?

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Why the study?

Does oral premedication with ketobemidone, lorazepam, or propranolol improve anxiety and perioperative outcomes in ASA I female patients undergoing elective laparoscopy?

Population

120 ASA I female patients scheduled for elective laparoscopy

Comparison

Oral premedication with ketobemidone 5 mg… vs Placebo

Design

RCT, randomized, double-blind

Follow-up

postoperative course

Authors

JJJan JakobssonKarolinska University HospitalKRK. RaneDanderyds sjukhusGRG. RybergSabbatsberg Hospital

Discussion

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Implication

No benefit over placebo in low-anxiety ASA I laparoscopy patients; challenges routine oral premedication and supports selective use only.

Structured PICO

Does oral premedication with ketobemidone, lorazepam, or propranolol improve anxiety and perioperative outcomes in ASA I female patients undergoing elective laparoscopy?

P
Population
120 ASA I female patients scheduled for elective laparoscopy
I
Intervention
Oral premedication with ketobemidone 5 mg, lorazepam 1 mg, or propranolol 40 mg given about an hour prior to anaesthesia
C
Comparator
Placebo
O
Outcome
Patient evaluation of anxiety, nurse evaluation of premedication, induction and postoperative coursepatient reported

Routine use of small doses of oral premedication one hour before elective surgery in low-anxiety patients does not provide significant benefits over placebo.

Cite This Study

Jakobsson et al. (1995) studied this question.

synapsesocial.com/papers/6a7c11a3c2a640f0bcdf90fehttps://doi.org/10.1111/j.1399-6576.1995.tb04078.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pharmacologic and Clinical Aspects of Preoperative Medication1986 · 61 citations
  2. 2Double-Blind Comparison of Midazolam and Temazepam as Oral Premedicants for Outpatient Anaesthesia1989 · 15 citations
  3. 3Premedication: An audit1991 · 29 citations
  4. 4The Value of the Preoperative Visit by an Anesthetist1963 · 306 citations
  5. 5Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central Sensitization1993 · 1,692 citations