Patients with congestive heart failure exhibit a prolonged time delay in the baroreflex response when analyzed using lagged detrended fluctuation analysis.
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No immediate clinical implications for heart failure; leaves open whether baroreflex delay predicts outcomes or guides therapy.
This paper explores the possibility of applying statistical nonlinear physics methods to elucidate the underlying mechanisms controlling the heart rate. In particular, the presence of delays in RR interval dynamics is studied by using a lagged detrended fluctuation analysis. The results indicate that patients with congestive heart failure (CHF) have a prolonged time delay in the baroreflex response. Some implications of large delays for the functioning of autonomic control in subjects with CHF are discussed.
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Álvarez‐Ramírez et al. (2009) studied this question.
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