Why the study?
VOM ethanol infusion improves sinus rhythm maintenance in AF, but distal collateral circulation of VOM can pose a challenge to effective ethanol infusion.
Does slower ethanol injection with extended balloon occlusion time enable effective myocardium staining in atrial fibrillation patients with distal vein of Marshall collateral circulation?
Does slower ethanol injection with extended balloon occlusion time enable effective myocardium staining in atrial fibrillation patients with distal vein of Marshall collateral circulation?
A modified technique of slow ethanol injection with extended balloon occlusion time overcomes the challenge of distal collateral circulation during vein of Marshall ethanol infusion for atrial fibrillation ablation.
May support VOM ethanol infusion feasibility despite distal collaterals in AF ablation; leaves open efficacy in randomized trials.
BACKGROUND: The vein of Marshall (VOM) ethanol infusion improves sinus rhythm maintenance in patients with atrial fibrillation (AF). Distal collateral circulation of VOM can be a challenge to effective ethanol infusion. OBJECTIVE: This study aimed to evaluate the feasibility and efficacy of ethanol infusion in VOM with distal collateral circulation. METHODS: Patients with AF scheduled for catheter ablation and VOM ethanol infusion were consecutively enrolled. During the procedure, non-occluded coronary sinus angiography was first performed for VOM identification. After VOM identification, an over-the-wire angioplasty balloon was used for cannulation and occluded angiography of the VOM. Those with distal VOM collateral circulation were included in this study. A method of slower ethanol injection (2 mL over 5 min) plus additional balloon occlusion time for 3 min after each injection was used. RESULTS: Of 162 patients scheduled for VOM ethanol infusion, apparent distal VOM collateral circulation was revealed in seven (4.3%) patients. Five patients had collateral circulation to the left atrium, one to the right superior vena cava, and one to the great cardiac vein. Two patients did not undergo further ethanol infusion because of our inadequate experience during the early stage of the project. Five patients had successful VOM ethanol infusion with manifest localized myocardium staining. CONCLUSIONS: Ethanol infusion in VOM with distal collateral circulation can be solved by slow injection of ethanol and enough balloon occlusion time between multiple injections.
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Zhang et al. (2022) studied this question.
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