Why the study?
Does the combination of sildenafil and l-arginine improve clinical outcomes in a pregnant woman with Eisenmenger syndrome?
Does the combination of sildenafil and l-arginine improve clinical outcomes in a pregnant woman with Eisenmenger syndrome?
The combination of sildenafil and l-arginine may be an effective therapy for managing severe pulmonary hypertension due to Eisenmenger syndrome during pregnancy.
Answers are grounded in this paper and cite their sources.
May support adjunctive sildenafil plus l-arginine in pregnant Eisenmenger syndrome; hypothesis-generating and requires prospective validation.
In Brief BACKGROUND: Eisenmenger syndrome in pregnancy may be a life-threatening disease despite recent additions to the treatment options. CASE: We present a woman with severe pulmonary hypertension due to Eisenmenger syndrome treated during pregnancy and delivery and postpartum with l-arginine and sildenafil to enhance the nitric oxide pathway. This combination was associated with significant improvement in the mother's clinical and hemodynamic condition and fetal well-being. CONCLUSION: The concomitant use of sildenafil and l-arginine for the management of pulmonary hypertension in pregnancy, combined with multidisciplinary care, permitted a good outcome for the mother and her infant. Enhancement of the nitric oxide–cyclic guanine monophosphate pathway by sildenafil and l-arginine may constitute effective therapy for pulmonary hypertension in pregnancy.
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Lacassie et al. (2004) studied this question.
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