What question did this study set out to answer?

October 30, 2007Nephrology Dialysis TransplantationOpen Access

Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease

View Full Paper

Ask AI

Bookmark

Why the study?

Is applanation tonometry using the SphygmoCor system reproducible for assessing central hemodynamics in pre-dialysis CKD patients?

Population

19 pre-dialysis patients with chronic kidney disease stages 3-5, mean GFR 25.3 ml/min/1.73 m2

Design

Cross-sectional

Follow-up

within a week

Authors

MFMarie Frimodt‐MøllerUniversity of Copenhagen ANAnne Højager NielsenAarhus University AKAnne‐Lise KamperCopenhagen University Hospital

Discussion

Member takes

Implication

Supports PWV assessment in pre-dialysis CKD clinics; leaves open larger validation for routine or trial use.

Key Points

To evaluate the intra-observer, inter-observer, and day-to-day reproducibility of pulse-wave analysis and pulse-wave velocity using applanation tonometry in pre-dialysis chronic kidney disease.
Evaluated N=19 pre-dialysis patients with CKD stages 3–5 (mean GFR 25.3 ml/min/1.73 m², range 9.9–42.2) under standardized conditions.
Performed duplicate recordings of radial pressure waveforms and aortic/brachial pulse-wave velocity with two trained observers using the SphygmoCor system, repeating tests within one week.
Mean inter-observer and day-to-day differences (±2 SD) were 0.9 ± 15.8% and 2.6 ± 11.2% for augmentation index, and 0.3 ± 3.2 m/s and -0.7 ± 1.9 m/s for aortic PWV, respectively.
Mean inter-observer and day-to-day differences were -0.9 ± 15.5% and -0.4 ± 24.7% for subendocardial viability ratio, and 1.4 ± 13.3 mmHg and 0.3 ± 20.9 mmHg for aortic pulse pressure.
Intra-observer assessments across three sets of double measurements demonstrated consistent reproducibility, indicating limited sample sizes are required for future clinical trials.

Structured PICO

Is applanation tonometry using the SphygmoCor system reproducible for assessing central hemodynamics in pre-dialysis CKD patients?

Population

19 pre-dialysis patients with chronic kidney disease (CKD) stages 3-5, mean GFR 25.3 ml/min/1.73 m2 (range 9.9-42.2)

Intervention

Applanation tonometry using SphygmoCor software and hardware for pulse-wave analysis (PWA) and pulse-wave velocity (PWV)

Outcome

Intra- and inter-observer and day-to-day reproducibility of pulse-wave analysis (PWA) and pulse-wave velocity (PWV)surrogate

Applanation tonometry using the SphygmoCor system is a highly reproducible, non-invasive method for assessing central hemodynamics in pre-dialysis CKD patients.

Cite This Study

Frimodt‐Møller et al. (2007) studied this question.

synapsesocial.com/papers/6a7c1a2f169fe1af7cc2a3fc https://doi.org/10.1093/ndt/gfm470

View Full Paper

Ask AI

Bookmark

Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider