Why the study?
Does monitoring heparin therapy with APTT compared to chromogenic substrate assays result in discrepant heparin concentration classifications in patients with severe underlying diseases?
Population
47 patients receiving heparin therapy for various conditions including thromboembolism, myocardial…
Comparison
Activated partial thromboplastin time (APTT) assay vs Chromogenic substrate assays
Design
Cohort
Authors
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APTT may overestimate heparin levels in severe illness; leaves open whether chromogenic assays improve monitoring accuracy.
Does monitoring heparin therapy with APTT compared to chromogenic substrate assays result in discrepant heparin concentration classifications in patients with severe underlying diseases?
APTT may overestimate heparin concentrations in patients with severe underlying diseases due to non-heparin related prolongation, suggesting chromogenic assays may be more reliable in these populations.
Fey et al. (1987) studied this question.
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