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January 1, 2004AJP Heart and Circulatory Physiology

Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition

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Why the study?

Does the NHE-1 inhibitor EMD-87580 reverse hypertrophy and heart failure in a rat model of post-myocardial infarction?

Population

Male Sprague-Dawley rats subjected to coronary artery ligation to induce myocardial infarction and heart…

Comparison

NHE-1-specific inhibitor EMD-87580 provided in… vs Sham procedure or untreated myocardial infarction

Design

Preclinical

Follow-up

up to 3 months

Authors

LCLing ChenXiamen UniversityCCChang Xun ChenShanghai University of Traditional Chinese MedicineXGXiaohong Tracey GanWestern University

Discussion

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Implication

Hypothesis-generating for NHE-1 inhibition in post-MI remodeling; leaves open translation to human heart failure therapy.

Structured PICO

Does the NHE-1 inhibitor EMD-87580 reverse hypertrophy and heart failure in a rat model of post-myocardial infarction?

P
Population
Male Sprague-Dawley rats subjected to coronary artery ligation to induce myocardial infarction and heart failure
I
Intervention
NHE-1-specific inhibitor EMD-87580 provided in the diet, commenced immediately or 2-4 weeks after ligation
C
Comparator
Sham procedure or untreated myocardial infarction
O
Outcome
Hypertrophy and hemodynamics (including left ventricular end-diastolic pressure and systolic function) at up to 3 monthssurrogate

NHE-1 inhibition with EMD-87580 attenuates and reverses postinfarction remodeling and heart failure in rats, even when treatment is delayed up to 4 weeks.

Cite This Study

Chen et al. (2004) studied this question.

synapsesocial.com/papers/6a7c207124f98b6d3fc2b79bhttps://doi.org/10.1152/ajpheart.00602.2003
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Also Consider

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