Key result
The NHE inhibitor cariporide limited postinfarction myocyte dimensional changes to <1% compared to 14-19% increases in controls, and abrogated elevations in left ventricular end-diastolic pressure.
Why the study?
Does cariporide attenuate early postinfarction myocyte remodeling and heart failure in a rat model of myocardial infarction?
Population
Male Sprague-Dawley rats subjected to left main coronary artery ligation
Comparison
Cariporide supplemented in diet, started 1 week… vs Control diet
Design
Preclinical, randomized
Follow-up
1 week post-infarction
Authors
Loading...
Animal data suggest NHE inhibition curbs postinfarction remodeling; leaves open clinical translation to human heart failure prevention.
RCT
Randomized
Does cariporide attenuate early postinfarction myocyte remodeling and heart failure in a rat model of myocardial infarction?
Absolute Event Rate: 1% vs 14%
Inhibition of Na+/H+ exchange with cariporide attenuates early postinfarction myocyte remodeling and heart failure in a rat model, independent of infarct size.
Yoshida et al. (2000) conducted an RCT in Postinfarction hypertrophy and heart failure. Cariporide vs. Control diet was evaluated on Myocyte cell length increase. The NHE inhibitor cariporide limited postinfarction myocyte dimensional changes to <1% compared to 14-19% increases in controls, and abrogated elevations in left ventricular end-diastolic pressure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: