Key result
Cariporide reduced the depression of LV +dP/dt (23.1% vs 34%, P<0.01) and the increase in LV end-diastolic pressure (447% vs 1225%) in rats with large infarcts after coronary artery ligation.
Why the study?
Does cariporide reduce hypertrophy and heart failure progression in rats after myocardial infarction?
Population
Rats subjected to occlusion (or sham) of the left main coronary artery (coronary artery ligation model)
Comparison
Cariporide administered via diet immediately… vs Control diet
Design
Preclinical
Follow-up
13-15 weeks
Authors
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Does not support clinical use of cariporide post-MI; leaves open whether NHE-1 inhibition attenuates human post-infarct remodeling.
Does cariporide reduce hypertrophy and heart failure progression in rats after myocardial infarction?
Absolute Event Rate: 23.1% vs 34%
p-value: p=<0.01
NHE-1 inhibition with cariporide attenuates hypertrophy and heart failure progression after myocardial infarction in a rat model.
Kusumoto et al. (2001) studied Myocardial infarction and heart failure. Cariporide vs. Control diet was evaluated on Depression of left ventricular increase in pressure over time (LV +dP/dt) in large infarcts (p=<0.01). Cariporide reduced the depression of LV +dP/dt (23.1% vs 34%, P<0.01) and the increase in LV end-diastolic pressure (447% vs 1225%) in rats with large infarcts after coronary artery ligation.
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