March 1, 2002Cardiovascular ResearchOpen Access

Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger

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Why the study?

Does cariporide reduce cardiac hypertrophy in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR)

Comparison

Cariporide orally for 1 month vs Nifedipine orally for 1 month and untreated…

Design

Preclinical

Follow-up

1 month

Authors

MHMarı́a C. Camilión de HurtadoBoehringer Ingelheim (Germany)

Discussion

Member takes

Implication

Attenuates hypertrophy in SHR model; extends preclinical NHE inhibition data but leaves human translation open.

Structured PICO

Does cariporide reduce cardiac hypertrophy in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR)

Intervention

Cariporide (0.3 and 3.0 mg/kg/day) orally for 1 month

Comparator

Nifedipine (10.0 mg/kg/day) orally for 1 month and untreated control

Outcome

Heart weight to body weight ratiosurrogate

Chronic inhibition of the Na+/H+ exchanger with cariporide induces regression of pathological cardiac hypertrophy in spontaneously hypertensive rats, independent of significant blood pressure reduction.

Cite This Study

Marı́a C. Camilión de Hurtado (2002) studied this question.

synapsesocial.com/papers/6a714c8435aa2c282ce29b5c https://doi.org/10.1016/s0008-6363(01)00544-2

Topics

Hypertension management

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Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider