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March 1, 2007Canadian Journal of Physiology and Pharmacology

Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+/H+exchanger-1 (NHE-1) inhibitionThis paper is one of a selection of papers published in this Special Issue, entitled The Cellular and Molecular Basis of Cardiovascular Dysfunction, Dhalla 70th Birthday Tribute.

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Why the study?

Does NHE-1 inhibition induce cardiac hypertrophy regression via the calcineurin/NFAT pathway in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats with cardiac hypertrophy, and cultured neonatal rat ventricular myocytes…

Comparison

NHE-1 inhibitors cariporide and BIIB723 for 30… vs Untreated SHR and normotensive Wistar rats…

Design

Preclinical

Follow-up

30 days

Authors

IEIrene L. EnnisCentro de Investigaciones CardiovascularesCGCarolina D. GarciarenaRoyal College of Surgeons in IrelandEEEduardo M. EscuderoUniversity of Mannheim

Discussion

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Implication

NHE-1 inhibition may regress hypertrophy in hypertensive rat models; leaves open any role in human disease.

Structured PICO

Does NHE-1 inhibition induce cardiac hypertrophy regression via the calcineurin/NFAT pathway in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats (SHR) with cardiac hypertrophy, and cultured neonatal rat ventricular myocytes (NRVM) stimulated with endothelin-1
I
Intervention
NHE-1 inhibitors cariporide and BIIB723 for 30 days (in vivo); cariporide (in vitro)
C
Comparator
Untreated SHR and normotensive Wistar rats (in vivo); untreated ET-1-stimulated NRVM (in vitro)
O
Outcome
Cardiac hypertrophy regression (heart mass/body mass ratio) and calcineurin/NFAT pathway expressionsurrogate

NHE-1 inhibition induces regression of cardiac hypertrophy in spontaneously hypertensive rats, likely mediated by inactivation of the calcineurin/NFAT pathway.

Cite This Study

Ennis et al. (2007) studied this question.

synapsesocial.com/papers/6a714cc335aa2c282ce29ba1https://doi.org/10.1139/y06-072

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac function and morphology with aging in the spontaneously hypertensive rat1979 · 231 citations
  2. 2Regression of Hypertensive Myocardial Fibrosis by Na + /H + Exchange Inhibition2003 · 63 citations
  3. 3Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy2003 · 775 citations
  4. 4A new generation of Ca2+ indicators with greatly improved fluorescence properties.1985 · 21,776 citations
  5. 5Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition2004 · 91 citations