This work demonstrates the electroreductive transformation of aliphatic ketones and aldehydes using dithioacetals, indicating a new synthetic approach.
In this work, we identify dithioacetals as synthetically accessible, redox-active, and traceless activating groups that enable the electroreductive transformation of aliphatic ketones and aldehydes. This strategy effectively converts these carbonyl compounds into dianion equivalents to undergo deoxygenative gem-difunctionalization with various electrophiles. Faradaic control was achieved over reaction chemoselectivity, allowing for the combinatorial construction of densely functionalized silanes, boronates, and germanes.
No takes yet. Share an insight, caveat, or question.
Cemalovic et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: