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August 12, 2026Respiratory ResearchOpen Access

Evaluation of aerosol delivery in ventilated patients via vibrating mesh nebuliser versus other delivery devices using a patient-specific in silico whole-lung model

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Authors

ATArash TakiBMBarry MurphyJRJakob Richter

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Overview

Randomized trial evaluates aerosol delivery efficiency in ventilated patients, highlighting device impact on deposition patterns.

Key Points

  • This research aims to assess aerosol deposition in mechanically ventilated patients using a patient-specific lung model.
  • Developed a subject-specific whole-lung model using Digital Twinhale® technology with CT data.
  • Simulated aerosol transport with three-dimensional Lagrangian particle dynamics across different nebuliser devices.
  • Evaluated aerosol deposition from a vibrating mesh nebuliser under varied ventilatory conditions.
  • A-VMN achieved the highest deposited mass fraction in all lung regions compared to other devices.
  • B1 flow profile resulted in maximum deposition, while B2 led to increased dose loss during exhalation.
  • Flow profiles did not significantly alter central-to-peripheral deposition ratios, indicating aerosol characteristics as primary factors.

Cite This Study

Taki et al. (2026) studied this question.

synapsesocial.com/papers/6a7c20ae06a85aed514b7ab0https://doi.org/10.1186/s12931-026-03865-2
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