Autocrine regulation of rat chondrocyte proliferation by natriuretic peptide C and its receptor, natriuretic peptide receptor-B.

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Population

Rat tissues (xiphoid cartilage, brain, lung, liver, adrenal gland, and kidney) and cultured rat chondrocytes

Design

Preclinical

Authors

Discussion

CNP may inhibit chondrocyte mitogenesis via NPR-B; leaves open relevance to human cartilage disorders.

Population

Rat tissues (xiphoid cartilage, brain, lung, liver, adrenal gland, and kidney) and cultured rat chondrocytes

Intervention

C-type natriuretic peptide (CNP), atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and TGF-beta 1

Outcome

Intracellular cGMP production and [3H]thymidine incorporation (mitogenesis)surrogate

Autocrine CNP inhibits mitogenesis in rat chondrocytes via NPR-B under the control of TGF-beta 1.

Hagiwara et al. (1994) studied this question.

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