February 1, 2011Hypertension
Effects of the Angiotensin Receptor Blocker Azilsartan Medoxomil Versus Olmesartan and Valsartan on Ambulatory and Clinic Blood Pressure in Patients With Stages 1 and 2 Hypertension
Why the study?
Does azilsartan medoxomil reduce 24-hour mean systolic BP more than valsartan, olmesartan, or placebo in patients with Stages 1 and 2 hypertension?
Population
1,291 patients with Stages 1 and 2 hypertension, mean age 56 years, 54% men, with a baseline 24-hour mean…
Comparison
Azilsartan medoxomil at 40 mg or 80 mg. vs Valsartan 320 mg, olmesartan medoxomil 40 mg…
Design
RCT, randomized, double-blind, placebo-controlled
Authors
Discussion
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Implication
Azilsartan 80 mg may be preferred for greater 24-hour SBP reduction versus maximal valsartan or olmesartan; extends comparative ARB potency data in hypertension.
Structured PICO
Does azilsartan medoxomil reduce 24-hour mean systolic BP more than valsartan, olmesartan, or placebo in patients with Stages 1 and 2 hypertension?
P
Population
1,291 patients with Stages 1 and 2 hypertension, mean age 56 years, 54% men, with a baseline 24-hour mean systolic BP of 145 mm Hg.
I
Intervention
Azilsartan medoxomil at 40 mg or 80 mg.
C
Comparator
Valsartan 320 mg, olmesartan medoxomil 40 mg, and matching placebo.
O
Outcome
Change from baseline in 24-hour mean systolic BP.surrogate
Azilsartan medoxomil at its maximal dose (80 mg) provides superior 24-hour systolic blood pressure reduction compared to maximal approved doses of valsartan and olmesartan in patients with stage 1 and 2 hypertension.
Cite This Study
White et al. (2011) studied this question.