Population
Guinea-pig ventricular myocytes
Comparison
Superfusion with hyperosmotic Tyrode solution… vs Normal osmolality (control)
Design
Preclinical
Follow-up
up to 40 min
Authors
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May alter ventricular myocyte excitability in hyperosmolar states; leaves open translation to human arrhythmia risk.
Hyperosmotic stress modifies electrical activity in ventricular myocytes primarily through changes in intracellular K+, Na+, and Ca2+ concentrations affecting specific membrane currents.
Ogura et al. (1997) studied this question.
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