What question did this study set out to answer?

To review the electrophysiologic rationale and clinical utility of magnesium as an adjunctive therapy and monotherapy in the management of atrial arrhythmias.

June 3, 2013Pacing and Clinical Electrophysiology

Magnesium Adjunctive Therapy in Atrial Arrhythmias

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Population

Patients with atrial arrhythmias, including those undergoing cardiothoracic surgery

Design

Review

Authors

HGHarsha V. GangaUniversity of Massachusetts Chan Medical School ANAdam M. NoyesBrown University CWC Michael WhiteGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Should not yet change practice for postoperative AF; leaves open need for RCTs to confirm efficacy and safety.

Key Points

To review the electrophysiologic rationale and clinical utility of magnesium as an adjunctive therapy and monotherapy in the management of atrial arrhythmias.
Examined cardiac metabolic and electrophysiologic roles of intracellular versus serum magnesium in arrhythmia development.
Assessed outcomes of magnesium supplementation in combination with standard antiarrhythmic drugs and as monotherapy in cardiothoracic surgery.
Intracellular magnesium deficiency occurs in a substantial proportion of patients with arrhythmias despite normal serum magnesium levels.
Magnesium adjunctive therapy improves atrial antiarrhythmic drug efficacy while reducing the potential for drug-induced proarrhythmia.
Magnesium monotherapy provides direct antiarrhythmic efficacy in patients undergoing cardiothoracic surgery.

Structured PICO

Population

Patients with atrial arrhythmias, including those undergoing cardiothoracic surgery

Intervention

Magnesium adjunctive therapy or monotherapy

Magnesium supplementation may improve the efficacy and safety profile of antiarrhythmic therapy for atrial arrhythmias.

Cite This Study

Ganga et al. (2013) studied this question.

synapsesocial.com/papers/6a7c326e073f483584dfbd06 https://doi.org/10.1111/pace.12189

Topics

Persistent AF management Atrial fibrillation

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Magnesium Adjunctive Therapy in Atrial Arrhythmias

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Magnesium Adjunctive Therapy in Atrial Arrhythmias

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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