Why the study?
Does tolamolol improve exercise tolerance compared to propranolol in patients with angina pectoris?
Does tolamolol improve exercise tolerance compared to propranolol in patients with angina pectoris?
Tolamolol, a new cardioselective beta-blocker, improves exercise tolerance in patients with angina pectoris similarly to propranolol without causing significant airway resistance.
May support tolamolol as cardioselective option in angina; leaves open confirmation in randomized trials.
The effect of oral and intravenous tolamolol on exercise tolerance was assessed in 11 patients with angina pectoris. Patients were selected on the basis of an absence of placebo response and the reliable reproducibility of anginal pain and electrocardiographic changes with exercise on a constant load Schönander-Elema bicycle ergometer. The effect of tolamolol on exercise time and heart rate was compared with that of propranolol. Tolamolol was shown to increase exercise tolerance and the effect was comparable to that of propranolol. Tolamolol did not produce a significant increase in airways resistance nor were any untoward side effects noted.
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Sood et al. (1973) studied this question.
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