Why the study?
How do tolamolol, propranolol, and practolol compare in antagonizing isoprenaline- and exercise-induced tachycardia in conscious dogs?
How do tolamolol, propranolol, and practolol compare in antagonizing isoprenaline- and exercise-induced tachycardia in conscious dogs?
Antagonism of exercise-induced tachycardia may provide a more meaningful assessment of the therapeutic potential of beta-blockers than isoprenaline-induced tachycardia.
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Tolamolol's model-specific potency in dogs warrants caution extrapolating to humans; leaves open whether exercise antagonism better predicts therapeutic beta-blockade.
The effects of tolamolol, propranolol and practolol on both isoprenaline- and exercise-induced tachycardia have been studied in conscious dogs. Tolamolol was approximately equipotent to propranolol and 50 times more potent than practolol in antagonizing exercise-induced tachycardias, but was approximately 12 times less potent than propranolol and 8 times more potent than practolol in blocking isoprenaline-induced tachycardia. It is suggested that antagonism of the tachycardia induced by exercise affords a more meaningful assessment of the possible therapeutic potential of beta-adrenoceptor blocking drugs than does that induced by isoprenaline.
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Adam et al. (1973) studied this question.
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