Why the study?
Does practolol compared to propranolol improve myocardial blood flow and physiological parameters in a canine model of acute myocardial infarction?
Population
Anaesthetized greyhounds before and after acute coronary artery ligation
Comparison
Practolol (0.5 mg/kg intravenously) vs Propranolol (0.1 mg/kg intravenously)
Design
Preclinical
Follow-up
2-3 hours after acute coronary artery ligation
Authors
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Animal data on cardioselective vs nonselective beta-blockade in ischaemia warrant clinical caution; leaves open relevance to human AMI.
Does practolol compared to propranolol improve myocardial blood flow and physiological parameters in a canine model of acute myocardial infarction?
In an experimental canine model of acute myocardial infarction, practolol preserved ischaemic myocardial blood flow and showed beneficial metabolic effects compared to propranolol, which worsened ischaemia.
Marshall et al. (1976) studied this question.
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