Why the study?
Does practolol reduce myocardial ischaemic injury after experimental coronary occlusion in dogs?
Does practolol reduce myocardial ischaemic injury after experimental coronary occlusion in dogs?
Practolol pretreatment reduces the extent and severity of myocardial ischaemic injury following acute coronary occlusion in a canine model without depressing ventricular function.
Does not support clinical use of practolol; leaves open translation of ischemic injury reduction to human acute coronary occlusion.
Epicardial electrocardiographic maps were used to assess the effect of practolol (2·5 mg/kg) on the extent and severity of myocardial ischaemic injury after acute coronary artery occlusion in dogs. The average ST segment elevation and number of sites with abnormally elevated ST segments were significantly reduced 15 min following occlusion after practolol pretreatment when compared with a previous 20 min control occlusion (4·7 ± 0·5 to 2·9 ± 0·6 mV and 8·4 ±0·3 to 5·1 ±0·7, respectively). Analysis of ventricular function in normal conscious animals indicated a lack of myocardial depressant effect of practolol, and this finding was confirmed in the group subjected to coronary occlusions.
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Libby et al. (1973) studied this question.
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