Why the study?
Do beta-receptor blocking agents depress myocardial function in conscious dogs before and after acute coronary artery occlusion?
Population
Conscious dogs before and after acute coronary artery occlusion
Comparison
dl-Propranolol, d-propranolol, and practolol… vs Baseline and d-propranolol
Design
Preclinical
Authors
Loading...
Beta-blocker cardiodepression in conscious dogs occurs via sympathetic inhibition, not quinidine-like effects; leaves open human translation.
Do beta-receptor blocking agents depress myocardial function in conscious dogs before and after acute coronary artery occlusion?
The cardiodepressant effect of beta-blockers is caused by inhibition of endogenous sympathetic tone rather than a quinidine-like action.
Liang et al. (1974) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: