What question did this study set out to answer?

Determine the clinical, electrocardiographic, and hemodynamic effects of intravenous propranolol on myocardial ischemia during temporary occlusion of the left anterior descending coronary artery.

April 1, 1986CirculationOpen Access

Effect of propranolol on myocardial ischemia occurring during acute coronary occlusion.

View Full Paper

Ask AI

Bookmark

Why the study?

Does short-term intravenous propranolol reduce myocardial ischemia during acute coronary occlusion in patients undergoing LAD angioplasty?

Key Points

Determine the clinical, electrocardiographic, and hemodynamic effects of intravenous propranolol on myocardial ischemia during temporary occlusion of the left anterior descending coronary artery.
Assessed 16 patients undergoing percutaneous transluminal angioplasty of the left anterior descending coronary artery.
Administered short-term intravenous nonselective beta-blockade with propranolol (0.1 mg/kg) during temporary balloon occlusion.
Quantified indexes of myocardial oxygen demand and regional supply, including great cardiac vein flow and coronary collateral resistance.
Propranolol prevented, delayed onset, or diminished the magnitude of myocardial ischemia in 10 of 16 patients while reducing heart rate, blood pressure, and rate-pressure product in all patients.
In patients who derived clinical benefit, regional oxygen supply was maintained without significant change in great cardiac vein flow (40 ± 15 to 41 ± 17 ml/min, p = NS) or collateral resistance (2.1 ± 1.0 to 2.1 ± 1.1 mm Hg/ml/min, p = NS).
In non-benefited patients, oxygen supply deteriorated, marked by decreased great cardiac vein flow (50 ± 10 to 39 ± 6 ml/min, p < .05) and increased collateral resistance (1.6 ± 0.5 to 2.0 ± 0.6 mm Hg/ml/min, p < .05).

Structured PICO

Does short-term intravenous propranolol reduce myocardial ischemia during acute coronary occlusion in patients undergoing LAD angioplasty?

Population

16 patients undergoing angioplasty of the left anterior descending coronary artery

Intervention

Short-term intravenous propranolol (0.1 mg/kg)

Outcome

Myocardial ischemia (clinical, electrocardiographic, and hemodynamic effects) during temporary coronary occlusionsurrogate

Intravenous propranolol can prevent or diminish myocardial ischemia during acute coronary occlusion primarily by decreasing myocardial oxygen demand rather than improving oxygen supply.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

IV propranolol may attenuate ischemia during coronary occlusion; leaves open need for randomized confirmation in acute settings.

Cite This Study

Feldman et al. (1986) studied this question.

synapsesocial.com/papers/6a1ee725f26b1ca3a088c699 https://doi.org/10.1161/01.cir.73.4.727

View Full Paper

Ask AI

Bookmark

Effect of propranolol on myocardial ischemia occurring during acute coronary occlusion.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Effect of propranolol on myocardial ischemia occurring during acute coronary occlusion.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider