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April 1, 1981Clinical Pharmacology & Therapeutics

Effect of atenolol, metoprolol, and propranolol on isoproterenol-induced tremor and tachycardia in normal subjects

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Why the study?

Do single oral doses of atenolol, metoprolol, or propranolol affect exercise tachycardia and isoproterenol-induced heart rate and tremor responses in normal subjects?

Population

6 normal subjects

Comparison

Single oral doses of atenolol, metoprolol, or… vs Placebo

Design

Other

Authors

EPEmilio PeruccaUniversité Claude Bernard Lyon 1HPH PicklesSt Bartholomew's HospitalARA. RichensUniversity of Parma

Discussion

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Implication

Propranolol's greater isoproterenol potency in healthy subjects cautions against assuming cardioselectivity equivalence; leaves open clinical relevance for tremor or arrhythmia management.

Structured PICO

Do single oral doses of atenolol, metoprolol, or propranolol affect exercise tachycardia and isoproterenol-induced heart rate and tremor responses in normal subjects?

P
Population
6 normal subjects
I
Intervention
Single oral doses of atenolol (100 mg), metoprolol (100 mg), or propranolol (40 mg)
C
Comparator
Placebo
O
Outcome
Exercise tachycardia and heart rate and finger tremor responses to graded injections of isoproterenolsurrogate

Propranolol is more potent than cardioselective beta-blockers at suppressing isoproterenol-induced tremor and tachycardia, likely due to peripheral beta-2 antagonism.

Cite This Study

Perucca et al. (1981) studied this question.

synapsesocial.com/papers/6a72fbd100f6302f2c9a2f1chttps://doi.org/10.1038/clpt.1981.59
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhancement of physiological finger tremor by intravenous isoprenaline infusions in man: evaluation of its role in the assessment of beta‐ adrenoceptor antagonists.1984 · 16 citations
  2. 2Inhibitory Effect of Metoprolol, a New Cardioselective β-Blockade, on Catecholamine-Induced Cardiac Ischemia1978
  3. 3A Comparison of the Cardioselectivity of Five β-Adrenoceptor Blocking Drugs1987 · 16 citations
  4. 4Observations on the mechanism underlying the differences in exercise and isoprenaline tachycardia after cardioselective and non‐selective beta‐adrenoceptor antagonists.1983 · 24 citations
  5. 5Comparison of the Inotropic and Chronotropic Effects of Metoprolol and Propranolol1981 · 6 citations