Why the study?
Do different beta-blockers (acebutolol, atenolol, betaxolol, metoprolol, propranolol) differ in cardioselectivity in normal subjects?
Population
6 normal subjects
Comparison
200 mg acebutolol, 50 mg atenolol, 10 mg… vs Placebo
Design
RCT, random order, double-blind
Authors
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Supports preferring cardioselective beta-blockers over propranolol when selectivity matters; confirms differential effects in this RCT.
Do different beta-blockers (acebutolol, atenolol, betaxolol, metoprolol, propranolol) differ in cardioselectivity in normal subjects?
Atenolol and betaxolol are more cardioselective than acebutolol, while all four are more cardioselective than propranolol.
Pringle et al. (1987) studied this question.
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