Key result
Single oral doses of bisoprolol (20 mg) showed slightly more potency and selectivity for beta-1 adrenoceptors than atenolol (100 mg) in healthy volunteers.
Why the study?
Does a single oral dose of bisoprolol demonstrate greater beta-1 adrenoceptor selectivity compared to atenolol in healthy volunteers?
Population
8 healthy volunteers
Comparison
Single oral dose of 20 mg bisoprolol vs Single oral dose of 100 mg atenolol, and placebo
Design
RCT, randomized order, double-blind
Authors
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Comparable selectivity in volunteers supports interchangeable dosing; leaves open differentiation in patients with comorbidities.
RCT (n=8)
Double-blind
randomized
Does a single oral dose of bisoprolol demonstrate greater beta-1 adrenoceptor selectivity compared to atenolol in healthy volunteers?
Bisoprolol is a highly selective beta-1 adrenoceptor antagonist with slightly greater selectivity than atenolol at the tested doses.
Chang et al. (1988) conducted an RCT in healthy volunteers (n=8). bisoprolol vs. atenolol 100 mg and placebo was evaluated on hemodynamic and biochemical changes induced by isoproterenol and exercise. Single oral doses of bisoprolol (20 mg) showed slightly more potency and selectivity for beta-1 adrenoceptors than atenolol (100 mg) in healthy volunteers.
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