Why the study?
Controlling blood pressure throughout the night is crucial to reduce complications, but the effect of antihypertensive medication timing and frequency on nighttime and 24-h blood pressure control required evaluation.
Does twice daily antihypertensive medication dosing improve nighttime and 24-h blood pressure control compared to once daily dosing in hypertensive patients with controlled office BP?
Population
199 hypertensive patients with controlled office blood pressure
Comparison
Once daily vs twice daily antihypertensive medications
Design
Comparative study
Authors
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Antihypertensive timing may affect nighttime BP; Level 5 data leaves open need for randomized confirmation.
Does twice daily antihypertensive medication dosing improve nighttime and 24-h blood pressure control compared to once daily dosing in hypertensive patients with controlled office BP?
Taking an extra antihypertensive pill at night (twice daily dosing) does not improve nighttime or 24-hour blood pressure control in patients with controlled office BP, and is associated with higher ambulatory BP and masked hypertension.
Youssef et al. (2020) studied this question.
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