Why the study?
Does switching nondiuretic antihypertensive medications to bedtime dosing reduce cardiovascular events compared to morning dosing in patients with hypertension and comorbid conditions?
Population
Patients with hypertension and other comorbid conditions
Comparison
Switching nondiuretic antihypertensive… vs Continuing morning dosing of all…
Design
Review, randomized
Follow-up
36 to 42 months
Authors
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Optimal antihypertensive dosing time remains uncertain in comorbid hypertension; leaves open bedtime benefit until pragmatic trial results emerge.
Does switching nondiuretic antihypertensive medications to bedtime dosing reduce cardiovascular events compared to morning dosing in patients with hypertension and comorbid conditions?
This paper reviews the rationale and design for a pragmatic clinical trial comparing bedtime versus morning dosing of antihypertensive medications to reduce cardiovascular events.
Carter et al. (2013) studied this question.
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