Why the study?
Nocturnal blood pressure is difficult to manage clinically, and while antihypertensive chronotherapy may offer better control, supporting clinical evidence remains controversial.
Does bedtime dosing of olmesartan and amlodipine improve nighttime systolic blood pressure reduction compared to morning dosing in patients with hypertension?
Population
720 patients with hypertension untreated or discontinued for 2 weeks at 15 hospitals in China
Comparison
Morning dosing vs bedtime dosing of olmesartan 20 mg and amlodipine 5 mg
Design
Multicenter randomized clinical trial
Follow-up
12 weeks
Authors
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Supports bedtime dosing for nocturnal BP control; extends chronotherapy evidence in hypertension RCTs.
Does bedtime dosing of olmesartan and amlodipine improve nighttime systolic blood pressure reduction compared to morning dosing in patients with hypertension?
Bedtime administration of antihypertensive medication significantly improves nocturnal blood pressure control and circadian rhythm without increasing the risk of nocturnal hypotension compared to morning dosing.
Ye et al. (2025) studied this question.
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