Why the study?
Does trandolapril once daily improve treatment compliance compared to captopril twice daily in hypertensive patients?
Population
162 hypertensive patients with diastolic BP 95-115 mm Hg
Comparison
Trandolapril 2 mg oral once daily for 6 months… vs Captopril 25 mg oral twice daily for 6 months…
Design
RCT, randomly allocated
Follow-up
6 months
Authors
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Supports once-daily dosing to boost adherence in hypertension; extends evidence favoring simplified regimens over twice-daily alternatives.
Does trandolapril once daily improve treatment compliance compared to captopril twice daily in hypertensive patients?
A once-daily antihypertensive regimen significantly improves treatment compliance, particularly by reducing delayed doses, compared to a twice-daily regimen.
Andrejak et al. (2000) studied this question.
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