Why the study?
Does trandolapril 1 mg once daily reduce blood pressure as effectively as 0.5 mg twice daily in patients with mild to moderate essential hypertension?
Population
31 patients with mild to moderate essential hypertension
Comparison
Trandolapril 1 mg once daily for 4 weeks vs Trandolapril 0.5 mg twice daily for 4 weeks
Design
RCT, randomized crossover, double-blind
Follow-up
4 weeks per treatment phase
Authors
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Supports once-daily trandolapril for equivalent overall BP control; extends dosing evidence for nocturnal systolic effects.
Does trandolapril 1 mg once daily reduce blood pressure as effectively as 0.5 mg twice daily in patients with mild to moderate essential hypertension?
Trandolapril 1 mg once daily and 0.5 mg twice daily provide comparable overall blood pressure reductions in mild to moderate hypertension, though twice-daily dosing may offer better nocturnal systolic control.
Poirier et al. (1993) studied this question.
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