Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1995American Journal of Hypertension

Trandolapril: A Clinical Profile

View Full Paper
Ask AI
Bookmark
Share

Why the study?

What is the clinical profile, efficacy, and safety of trandolapril for blood pressure control?

Population

Patients requiring blood pressure control

Comparison

Trandolapril (doses up to 2 mg) vs Other ACE inhibitors

Design

Review

Authors

PDP DELEEUWMaastricht University Medical Centre

Discussion

Loading...

Member takes

Overview

Supports trandolapril as a hypertension option; leaves open need for updated head-to-head RCTs.

Key Points

  • To evaluate the clinical profile, pharmacokinetic properties, antihypertensive efficacy, and long-term tolerability of the angiotensin converting enzyme inhibitor trandolapril.
  • Assessed blood pressure reduction across clinical doses up to and exceeding 2 mg.
  • Analyzed the in vivo metabolic conversion to the active metabolite trandolaprilat and its relationship with creatinine clearance and duration of ACE inhibition.
  • Blood pressure is effectively controlled in approximately 60% of patients at doses up to 2 mg, with only minimal additional reductions observed at higher doses.
  • Trandolaprilat clearance correlates significantly with creatinine clearance, requiring dose adjustments in cases of severe renal impairment.
  • Inhibition of ACE remains sustained even following treatment discontinuation, supporting safe administration over extended durations.

Structured PICO

What is the clinical profile, efficacy, and safety of trandolapril for blood pressure control?

P
Population
Patients requiring blood pressure control
I
Intervention
Trandolapril (doses up to 2 mg)
C
Comparator
Other ACE inhibitors
O
Outcome
Blood pressure controlsurrogate

Trandolapril is an effective, long-acting ACE inhibitor that controls blood pressure in approximately 60% of patients with a safety profile similar to other drugs in its class.

Cite This Study

P DELEEUW (1995) studied this question.

synapsesocial.com/papers/6a8bb95490fae8fd47e98d36https://doi.org/10.1016/0895-7061(95)00192-1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Trandolapril on 24-H Ambulatory Blood Pressure in Patients with Mild-to-Moderate Essential Hypertension1994 · 21 citations
  2. 2Reactive Hyperreninemia Is a Major Determinant of Plasma Angiotensin II During ACE Inhibition1990 · 170 citations
  3. 3Once‐Daily Trandolapril Compared with the Twice‐Daily Formulation in the Treatment of Mild to Moderate Essential Hypertension: Assessment by Conventional and Ambulatory Blood Pressures1993 · 9 citations