Why the study?
Does trandolapril reduce sitting diastolic pressure differently in black versus white patients with mild to moderate hypertension?
Population
298 patients (207 white and 91 black) with mild to moderate hypertension
Comparison
Trandolapril 1, 2, and 4 mg/d vs Placebo
Design
RCT, randomized, parallel study design, double-blind
Follow-up
6 weeks
Authors
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Black patients require higher trandolapril doses than white patients for equivalent BP reduction; confirms racial differences in ACE inhibitor responsiveness.
Does trandolapril reduce sitting diastolic pressure differently in black versus white patients with mild to moderate hypertension?
Black hypertensive patients require higher doses of the ACE inhibitor trandolapril to achieve similar blood pressure reductions as white patients, a difference not explained by differences in ACE activity reduction.
Weir et al. (1995) studied this question.
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