Key result
Ketamine-fentanyl was safer and more efficacious than ketamine-propofol for pediatric cardiac catheterization, yielding better oxygenation and hemodynamics despite prolonged recovery time.
Why the study?
Does a combination of ketamine-propofol compared to ketamine-fentanyl improve hemodynamics, oxygenation, and recovery in pediatric patients undergoing cardiac catheterization?
Population
36 children aged 1 to 8 years, with right-to-left shunt scheduled for cardiac catheterization in Mansoura…
Comparison
Ketamine and propofol as induction agents… vs Ketamine and fentanyl as induction agents…
Design
RCT, randomized
Authors
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Favors ketamine-fentanyl over ketamine-propofol for pediatric cardiac catheterization; extends RCT evidence on sedation choices in congenital heart disease.
RCT (n=36)
randomized
No
Does a combination of ketamine-propofol compared to ketamine-fentanyl improve hemodynamics, oxygenation, and recovery in pediatric patients undergoing cardiac catheterization?
In pediatric patients with right-to-left shunts undergoing cardiac catheterization, a ketamine-fentanyl combination provides better oxygenation and hemodynamic stability than ketamine-propofol, albeit with a longer recovery time.
Deen et al. (2011) conducted an RCT in Right-to-left shunt requiring cardiac catheterization (n=36). Ketamine-propofol vs. Ketamine-fentanyl (Induction: ketamine 1 mg/kg and fentanyl 1 μg/kg; Maintenance: ketamine 25 μg/kg/min and fentanyl 0.75 μg/kg/min) was evaluated on Safety and efficacy (hemodynamic, oxygenation, recovery variables, and side effects). Ketamine-fentanyl was safer and more efficacious than ketamine-propofol for pediatric cardiac catheterization, yielding better oxygenation and hemodynamics despite prolonged recovery time.
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