Key result
Female gender was not associated with significant pre-hospital delay compared to men (unadjusted median 132 vs 113 min; adjusted P=0.15), nor was minority ethnicity.
Why the study?
Does female gender or ethnic minority status increase symptom-to-door time in patients presenting with STEMI?
Observational (n=1,020)
Does female gender or ethnic minority status increase symptom-to-door time in patients presenting with STEMI?
Absolute Event Rate: 132% vs 113%
p-value: p=0.15
Neither female gender nor ethnicity were associated with significant pre-hospital delay in STEMI patients undergoing primary PCI.
STEMI pre-hospital delays appear similar by gender and ethnicity; leaves open generalizability and need for targeted interventions in other cohorts.
BACKGROUND: Studies have shown higher in-hospital mortality for female patients and ethnic minorities admitted to hospital with acute ST elevation myocardial infarction (STEMI). Pre-hospital delay is thought to be associated with increased in-hospital mortality. AIM: To assess the impact of gender and ethnicity on symptom-to-door time (STDT) in patients presenting with STEMI. DESIGN: Retrospective survey of consecutive patients receiving primary percutaneous coronary intervention between January 2008 and January 2013. A multivariate model was used to adjust for confounders. MAIN OUTCOME MEASURE: Influence of gender and ethnicity on STDT. RESULTS: We analysed 1020 patients (75% male, 263 South Asians, 38 Afro Caribbeans and 719 White Europeans.) There was a trend towards longer unadjusted median STDT in women compared with men (132 min vs. 113 min P = 0.07) which disappeared after correction for age and ethnicity (P = 0.15). There was no gender difference in hospital mortality after correction for age (odds ratio 0.69, 95% confidence interval 0.40-1.18, P = 0.17). On linear regression analysis South Asians showed a trend towards longer STDT than other ethnic groups (P = 0.08) however after adjustment for diabetes there was no association between South Asian ethnicity and hospital mortality. CONCLUSIONS: Neither female gender nor ethnicity were shown to be associated with significant pre-hospital delay.
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Brown et al. (2015) conducted an observational in ST elevation myocardial infarction (STEMI) (n=1,020). Female gender and minority ethnicity vs. Male gender and White European ethnicity was evaluated on Symptom-to-door time (STDT) (p=0.15). Female gender was not associated with significant pre-hospital delay compared to men (unadjusted median 132 vs 113 min; adjusted P=0.15), nor was minority ethnicity.
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