Key result
Although crude in-hospital and long-term mortality was higher in women with STEMI undergoing primary PCI, this difference generally disappeared after adjusting for baseline and procedural characteristics such as older age and longer symptom-to-balloon time.
Why the study?
Does female gender worsen mortality in STEMI patients treated with primary PCI?
Population
64,366 patients with STEMI treated with primary PCI without prior thrombolysis from 21 studies.
Comparison
Primary PCI in women vs Primary PCI in men
Design
Systematic_review
Follow-up
up to 2-7 years
Authors
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Sex differences in STEMI mortality after primary PCI disappear after adjustment; confirms focus on age, risk profiles, and treatment delays rather than gender.
Systematic Review (n=64,366)
Does female gender worsen mortality in STEMI patients treated with primary PCI?
Absolute Event Rate: 8% vs 4%
p-value: p=<0.0001
Higher mortality in women with STEMI treated with primary PCI is largely explained by their older age, unfavorable risk profile, and longer symptom-to-balloon time rather than female gender itself.
Meer et al. (2015) conducted a systematic review in ST elevation myocardial infarction (STEMI) (n=64,366). Female gender vs. Male gender was evaluated on Crude in-hospital mortality (p=<0.0001). Although crude in-hospital and long-term mortality was higher in women with STEMI undergoing primary PCI, this difference generally disappeared after adjusting for baseline and procedural characteristics such as older age and longer symptom-to-balloon time.
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