Key result
Excess weight in children and adolescents was associated with significantly higher renal cortical stiffness compared to lean controls (mean shear wave velocity 3.09 m/s vs 2.79 m/s, p=0.001).
Why the study?
The study was conducted to determine the early effects of excess weight on renal cortical stiffness in children and adolescents using point shear wave elastography.
Does excess weight increase renal cortical stiffness measured by point shear wave elastography in children and adolescents?
Observational (n=194)
No
Does excess weight increase renal cortical stiffness measured by point shear wave elastography in children and adolescents?
Absolute Event Rate: 3.09% vs 2.79%
p-value: p=0.001
Excess weight in children and adolescents is associated with increased renal cortical stiffness, suggesting early adverse renal effects that can be detected non-invasively using point shear wave elastography.
May signal early renal changes in pediatric obesity; hypothesis-generating and requires prospective validation before clinical use.
AIM: To determine the early effects of excess weight on renal cortical stiffness in children and adolescents using point shear wave elastography (pSWE). MATERIALS AND METHODS: One hundred and forty-six overweight and obese children (43.2% male; mean age, 12.6±2.9 years: range 4.3-18) and 48 lean children (27.1% male: mean age, 12.4±3.4: range 4.8-18.9) were included in the study and control group, respectively. pSWE measurements of the two kidneys were performed. The mean value of shear wave velocity was compared between groups. RESULTS: The mean shear wave velocity was 2.79±0.53 m/s for the control subjects and 3.09±0.59 m/s for the overweight-obese subjects. The differences between the two groups were sta-tistically significant (p=0.001). There was no correlation between shear wave velocity and age or depth. A positive correlation was found between shear wave velocity and body mass index, body mass index-standard deviation score. CONCLUSION: Renal cortical stiffness was higher in children with excess weight than in lean children. This study is the first attempt at applying pSWE to investigate the early adverse effects of excess weight.
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Karaman et al. (2021) conducted an observational in Childhood obesity and overweight (n=194). Excess weight (overweight and obesity) vs. Lean (normal weight) was evaluated on Mean shear wave velocity (SWV) of the renal cortex (p=0.001). Excess weight in children and adolescents was associated with significantly higher renal cortical stiffness compared to lean controls (mean shear wave velocity 3.09 m/s vs 2.79 m/s, p=0.001).
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