Key result
Adherence therapy significantly reduced systolic blood pressure by 23.11 mm Hg compared with treatment as usual at 11 weeks in non-compliant patients with hypertension.
Why the study?
Does adherence therapy reduce systolic blood pressure in non-compliant hypertensive patients?
RCT (n=136)
Single-blind
Computer generated randomisation list in randomly permuted blocks of four and six
Yes
Does adherence therapy reduce systolic blood pressure in non-compliant hypertensive patients?
Mean Difference: -23.11 (95% CI -25.85–-20.36)
Absolute Event Rate: -22.1% vs 1%
p-value: p=<0.01
A 7-week adherence therapy intervention significantly improved medication adherence and led to clinically important reductions in systolic and diastolic blood pressure in non-compliant hypertensive patients.
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Adherence therapy improves BP control in non-compliant hypertensives; confirms efficacy of targeted interventions and supports clinical adoption with durability trials.
Alhalaiqa et al. (2011) conducted an RCT in Hypertension (n=136). Adherence therapy vs. Treatment as usual was evaluated on Difference in systolic blood pressure (SBP) from baseline to 11-weeks follow-up (MD -23.11, 95% CI -25.85 to -20.36, p=<0.01). Adherence therapy significantly reduced systolic blood pressure by 23.11 mm Hg compared with treatment as usual at 11 weeks in non-compliant patients with hypertension.
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