Key result
22 weeks of high-intensity resistance training in previously untrained men significantly increased indexed left ventricular myocardial mass by 1.7 g/m2 compared to inactive controls.
Why the study?
Does high intensity resistance training induce structural and functional cardiac adaptation in previously untrained middle-aged men?
RCT (n=80)
Single-blind
1:1:1 uniform allocation rate
No
Does high intensity resistance training induce structural and functional cardiac adaptation in previously untrained middle-aged men?
22 weeks of high-intensity resistance training in previously untrained men induces measurable, balanced physiological increases in left and right ventricular mass and volume without pathological remodeling.
Answers are grounded in this paper and cite their sources.
High-intensity resistance training induces physiological ventricular remodeling in untrained men; extends cardiac adaptation evidence to resistance modalities.
OBJECTIVE: Although musculoskeletal effects in resistance training are well described, little is known about structural and functional cardiac adaption in formerly untrained subjects. We prospectively evaluated whether short term high intensity (resistance) training (HI(R)T) induces detectable morphologic cardiac changes in previously untrained men in a randomized controlled magnetic resonance imaging (MRI) study. MATERIALS AND METHODS: 80 untrained middle-aged men were randomly assigned to a HI(R)T-group (n = 40; 43.5±5.9 years) or an inactive control group (n = 40; 42.0±6.3 years). HI(R)T comprised 22 weeks of training focusing on a single-set to failure protocol in 2-3 sessions/week, each with 10-13 exercises addressing main muscle groups. Repetitions were decreased from 8-10 to 3-5 during study period. Before and after HI(R)T all subjects underwent physiologic examination and cardiac MRI (cine imaging, tagging). RESULTS: Indexed left (LV) and right ventricular (RV) volume (LV: 76.8±15.6 to 78.7±14.8 ml/m2; RV: 77.0±15.5 to 78.7±15.1 ml/m2) and mass (LV: 55.5±9.7 to 57.0±8.8 g/m2; RV: 14.6±3.0 to 15.0±2.9 g/m2) significantly increased with HI(R)T (all p<0.001). Mean LV and RV remodeling indices of HI(R)T-group did not alter with training (0.73g/mL and 0.19g/mL, respectively [p = 0.96 and p = 0.87]), indicating balanced cardiac adaption. Indexed LV (48.4±11.1 to 50.8±11.0 ml/m2) and RV (48.5±11.0 to 50.6±10.7 ml/m2) stroke volume significantly increased with HI(R)T (p<0.001). Myocardial strain and strain rates did not change following resistance exercise. Left atrial volume at end systole slightly increased after HI(R)T (36.2±7.9 to 37.0±8.4 ml/m2, p = 0.411), the ratio to end-diastolic LV volume at baseline and post-training was unchanged (0.47 vs. 0.47, p = 0.79). CONCLUSION: 22 weeks of HI(R)T lead to measurable, physiological changes in cardiac atrial and ventricular morphologic characteristics and function in previously untrained men. TRIAL REGRISTRATION: The PUSH-trial is registered at the US National Institutes of Health (ClinicalTrials.gov), NCT01766791.
No takes yet. Share an insight, caveat, or question.
Scharf et al. (2017) conducted an RCT in Untrained healthy men (n=80). High intensity resistance training (HI(R)T) vs. Inactive control was evaluated on Change in left ventricular myocardial mass index from baseline to 22 weeks (g/m2) (MD 1.7, 95% CI 1.1-2.3, p=<0.001). 22 weeks of high-intensity resistance training in previously untrained men significantly increased indexed left ventricular myocardial mass by 1.7 g/m2 compared to inactive controls.
Synapse has enriched 10 related papers. Consider them for comparative context: